Second generation antipsychotic side effects

Side effect Aripiprazole Clozapine Olanzapine Quetiapine Risperidone Ziprasidone
Anticholinergic - +++ + +/- +/- +/-
EPS @ low dose + +/- +/- +/- + +/-
EPS - dose dependent + - + - ++ +
Orthostasis +/- +++ + ++ ++ +
Prolactin increase - - +/- +/- +++ +/-
QTc prolongation - + +/- +/- +/- +
Sedation - +++ ++ ++ + +
Lower seizure threshold ? ++ +/- +/- +/- +/-
Weight gain - +++ ++ + + +/-

For additional information, see Tandon (2002).